Heteromerization of TRP channel subunits: extending functional diversity
Protein & Cell
;
(12): 802-810, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-757438
ABSTRACT
Transient receptor potential (TRP) channels are widely found throughout the animal kingdom. By serving as cellular sensors for a wide spectrum of physical and chemical stimuli, they play crucial physiological roles ranging from sensory transduction to cell cycle modulation. TRP channels are tetrameric protein complexes. While most TRP subunits can form functional homomeric channels, heteromerization of TRP channel subunits of either the same subfamily or different subfamilies has been widely observed. Heteromeric TRP channels exhibit many novel properties compared to their homomeric counterparts, indicating that co-assembly of TRP channel subunits has an important contribution to the diversity of TRP channel functions.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Modelos Moleculares
/
Química
/
Estructura Terciaria de Proteína
/
Repetición de Anquirina
/
Estructura Cuaternaria de Proteína
/
Subunidades de Proteína
/
Canales Catiónicos TRPC
/
Dominios y Motivos de Interacción de Proteínas
/
Multimerización de Proteína
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2010
Tipo del documento:
Artículo
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