LSY-2 is essential for maintaining the germ-soma distinction in C. elegans
Protein & Cell
;
(12): 599-609, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-757565
ABSTRACT
The mechanisms that specify and maintain the characteristics of germ cells during animal development are poorly understood. In this study, we demonstrated that loss of function of the zinc-finger gene lsy-2 results in various somatic cells adopting germ cells characteristics, including expression of germline-specific P granules, enhanced RNAi activity and transgene silencing. The soma to germ transformation in lsy-2 mutants requires the activities of multiple chromatin remodeling complexes, including the MES-4 complex and the ISW-1 complex. The distinct germline-specific features in somatic cells and the gene expression profile indicate that LSY-2 acts in the Mec complex in this process. Our study demonstrated that lsy-2 functions in the maintenance of the soma-germ distinction.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Factores de Transcripción
/
Animales Modificados Genéticamente
/
Caenorhabditis elegans
/
Adenosina Trifosfatasas
/
Técnica del Anticuerpo Fluorescente Indirecta
/
Genes Esenciales
/
Perfilación de la Expresión Génica
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Proteínas de Caenorhabditis elegans
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Interferencia de ARN
/
Proteínas Fluorescentes Verdes
Límite:
Animales
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2015
Tipo del documento:
Artículo
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