Three-dimensional regulation of transcription
Protein & Cell
;
(12): 241-253, 2015.
Artículo
en Inglés
| WPRIM
| ID: wpr-757601
ABSTRACT
Cells can adapt to environment and development by reconstructing their transcriptional networks to regulate diverse cellular processes without altering the underlying DNA sequences. These alterations, namely epigenetic changes, occur during cell division, differentiation and cell death. Numerous evidences demonstrate that epigenetic changes are governed by various types of determinants, including DNA methylation patterns, histone posttranslational modification signatures, histone variants, chromatin remodeling, and recently discovered chromosome conformation characteristics and non-coding RNAs (ncRNAs). Here, we highlight recent efforts on how the two latter epigenetic factors participate in the sophisticated transcriptional process and describe emerging techniques which permit us to uncover and gain insights into the fascinating genomic regulation.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Transcripción Genética
/
Cromatina
/
Histonas
/
Diferenciación Celular
/
División Celular
/
Química
/
Procesamiento Proteico-Postraduccional
/
Muerte Celular
/
Metilación de ADN
/
ARN no Traducido
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2015
Tipo del documento:
Artículo
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