USP33, a new player in lung cancer, mediates Slit-Robo signaling
Protein & Cell
;
(12): 704-713, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-757656
ABSTRACT
Ubiquitin specific protease 33 (USP33) is a multifunctional protein regulating diverse cellular processes. The expression and role of USP33 in lung cancer remain unexplored. In this study, we show that USP33 is down-regulated in multiple cohorts of lung cancer patients and that low expression of USP33 is associated with poor prognosis. USP33 mediates Slit-Robo signaling in lung cancer cell migration. Downregulation of USP33 reduces the protein stability of Robo1 in lung cancer cells, providing a previously unknown mechanism for USP33 function in mediating Slit activity in lung cancer cells. Taken together, USP33 is a new player in lung cancer that regulates Slit-Robo signaling. Our data suggest that USP33 may be a candidate tumor suppressor for lung cancer with potential as a prognostic marker.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fisiología
/
Pronóstico
/
Inmunohistoquímica
/
Receptores Inmunológicos
/
Transducción de Señal
/
Regulación hacia Abajo
/
Regulación Neoplásica de la Expresión Génica
/
Movimiento Celular
/
Western Blotting
Tipo de estudio:
Estudio de etiología
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS