The role of BRCA1 in DNA damage response
Protein & Cell
; (12): 117-123, 2010.
Article
en En
| WPRIM
| ID: wpr-757722
Biblioteca responsable:
WPRO
ABSTRACT
BRCA1 is a well-established tumor suppressor gene, which is frequently mutated in familial breast and ovarian cancers. The gene product of BRCA1 functions in a number of cellular pathways that maintain genomic stability, including DNA damage-induced cell cycle checkpoint activation, DNA damage repair, protein ubiquitination, chromatin remodeling, as well as transcriptional regulation and apoptosis. In this review, we discuss recent advances regarding our understanding of the role of BRCA1 in tumor suppression and DNA damage response, including DNA damage-induced cell cycle checkpoint activation and DNA damage repair.
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Neoplasias Ováricas
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Fisiología
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Daño del ADN
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Neoplasias de la Mama
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Transducción de Señal
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Genes Supresores de Tumor
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Apoptosis
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Genes cdc
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Proteína BRCA1
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Reparación del ADN
Límite:
Female
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Humans
Idioma:
En
Revista:
Protein & Cell
Año:
2010
Tipo del documento:
Article