SUMOylation of RIG-I positively regulates the type I interferon signaling
Protein & Cell
;
(12): 275-283, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-757728
ABSTRACT
Retinoic acid-inducible gene-I (RIG-I) functions as an intracellular pattern recognition receptor (PRR) that recognizes the 5'-triphosphate moiety of single-stranded RNA viruses to initiate the innate immune response. Previous studies have shown that Lys63-linked ubiquitylation is required for RIG-I activation and the downstream anti-viral type I interferon (IFN-I) induction. Herein we reported that, RIG-I was also modified by small ubiquitin-like modifier-1 (SUMO-1). Functional analysis showed that RIG-I SUMOylation enhanced IFN-I production through increased ubiquitylation and the interaction with its downstream adaptor molecule Cardif. Our results therefore suggested that SUMOylation might serve as an additional regulatory tier for RIG-I activation and IFN-I signaling.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Sitios de Unión
/
Secuencia de Bases
/
Células HeLa
/
Transducción de Señal
/
Interferón Tipo I
/
Química
/
Cartilla de ADN
/
Virus Sendai
/
Proteína SUMO-1
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2010
Tipo del documento:
Artículo
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