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MAPK signaling in inflammation-associated cancer development
Protein & Cell ; (12): 218-226, 2010.
Artículo en Inglés | WPRIM | ID: wpr-757734
ABSTRACT
Mitogen-activated protein (MAP) kinases comprise a family of protein-serine/threonine kinases, which are highly conserved in protein structures from unicellular eukaryotic organisms to multicellular organisms, including mammals. These kinases, including ERKs, JNKs and p38s, are regulated by a phosphorelay cascade, with a prototype of three protein kinases that sequentially phosphorylate one another. MAPKs transduce extracellular signals into a variety of cellular processes, such as cell proliferation, survival, death, and differentiation. Consistent with their essential cellular functions, MAPKs have been shown to play critical roles in embryonic development, adult tissue homeostasis and various pathologies. In this review, we discuss recent findings that reveal the profound impact of these pathways on chronic inflammation and, particularly, inflammation-associated cancer development.
Asunto(s)
Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sistema de Señalización de MAP Quinasas / Quinasas MAP Reguladas por Señal Extracelular / Proteínas Quinasas JNK Activadas por Mitógenos / Proteínas Quinasas p38 Activadas por Mitógenos / Inflamación / Metabolismo / Neoplasias Límite: Animales / Humanos Idioma: Inglés Revista: Protein & Cell Año: 2010 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sistema de Señalización de MAP Quinasas / Quinasas MAP Reguladas por Señal Extracelular / Proteínas Quinasas JNK Activadas por Mitógenos / Proteínas Quinasas p38 Activadas por Mitógenos / Inflamación / Metabolismo / Neoplasias Límite: Animales / Humanos Idioma: Inglés Revista: Protein & Cell Año: 2010 Tipo del documento: Artículo