Roles of the hemagglutinin of influenza A virus in viral entry and development of antiviral therapeutics and vaccines
Protein & Cell
;
(12): 342-354, 2010.
Artículo
en Inglés
| WPRIM
| ID: wpr-757756
ABSTRACT
Seasonal influenza epidemics and influenza pandemics caused by influenza A virus (IAV) has resulted in millions of deaths in the world. The development of anti-IAV vaccines and therapeutics is urgently needed for prevention and treatment of IAV infection and for controlling future influenza pandemics. Hemagglutinin (HA) of IAV plays a critical role in viral binding, fusion and entry, and contains the major neutralizing epitopes. Therefore, HA is an attractive target for developing anti-IAV drugs and vaccines. Here we have reviewed the recent progress in study of conformational changes of HA during viral fusion process and development of HA-based antiviral therapeutics and vaccines.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Virus de la Influenza A
/
Fisiología
/
Terapéutica
/
Vacunas contra la Influenza
/
Usos Terapéuticos
/
Alergia e Inmunología
/
Gripe Humana
/
Epidemias
/
Pandemias
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2010
Tipo del documento:
Artículo
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