MED12 mutations in human diseases
Protein & Cell
;
(12): 643-646, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-757775
ABSTRACT
The Mediator Complex plays key roles in activating gene transcription in eukaryotes. Mediator of RNA polymerase II transcription subunit 12 homolog (MED12) is a subunit of the Mediator Complex and regulates the activity of the complex. MED12 is involved in a variety of cellular activities, and mutations in MED12 gene impair MED12 activities and are associated with several diseases, including Opitz-Kaveggia syndrome, Lujan syndrome, uterine leiomyomas and prostate cancer. This review will discuss the biological function of MED12 and the relationship between MED12 mutations and diseases.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Ano Imperforado
/
Neoplasias de la Próstata
/
Transcripción Genética
/
Neoplasias Uterinas
/
Estreñimiento
/
Anomalías Craneofaciales
/
Predisposición Genética a la Enfermedad
/
Discapacidad Intelectual Ligada al Cromosoma X
/
Complejo Mediador
/
Agenesia del Cuerpo Calloso
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2013
Tipo del documento:
Artículo
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