Nuclear microRNAs and their unconventional role in regulating non-coding RNAs
Protein & Cell
;
(12): 325-330, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-757808
ABSTRACT
MicroRNAs (miRNAs) are small non-coding RNAs (ncRNAs) that are involved in post-transcriptional gene regulation. It has long been assumed that miRNAs exert their roles only in the cytoplasm, where they recognize their target protein-coding messenger RNAs (mRNAs), and result in translational repression or target mRNA degradation. Recent studies, however, have revealed that mature miRNAs can also be transported from the cytoplasm to the nucleus and that these nuclear miRNAs can function in an unconventional manner to regulate the biogenesis and functions of ncRNAs (including miRNAs and long ncRNAs), adding a new layer of complexity to our understanding of gene regulation. In this review, we summarize recent literature on the working model of these unconventional miRNAs and speculate on their biological significance. We have every reason to believe that these novel models of miRNA function will become a major research topic in gene regulation in eukaryotes.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ARN Mensajero
/
Núcleo Celular
/
Regulación de la Expresión Génica
/
Estabilidad del ARN
/
Citoplasma
/
MicroARNs
/
Eucariontes
/
ARN Largo no Codificante
/
Genética
/
Metabolismo
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2013
Tipo del documento:
Artículo
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