Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism
Protein & Cell
;
(12): 83-85, 2013.
Artículo
en Inglés
| WPRIM
| ID: wpr-757832
ABSTRACT
Recent studies have been raising doubts on the safety of induced pluripotent stem cells (iPSCs) and proposing that the process of reprogramming brought about copy number variations (CNVs) in iPSCs. However, a recent paper published in Nature provided evidence showing that most CNVs were pre-existed as somatic mosaicism but not resulted from the reprogramming. This new finding would profoundly reshape some previous thoughts and endorse the confidence of iPSCs in both research and therapy.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Medicina Regenerativa
/
Reprogramación Celular
/
Células Madre Pluripotentes Inducidas
/
Variaciones en el Número de Copia de ADN
/
Metabolismo
/
Mosaicismo
Límite:
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2013
Tipo del documento:
Artículo
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