New components of the necroptotic pathway
Protein & Cell
;
(12): 811-817, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-757853
ABSTRACT
Programmed necrosis, also known as necroptosis, has recently drawn great attention. As an important cellular regulation mechanism, knowledge of its signaling components is expanding. Necroptosisis demonstrated to be regulated by the RIP1 and RIP3 kinases, and its pathophysiological importance has been confirmed in a number of disease models. Here we review the new members of this necroptosis pathway, MLKL, PGAM5, Drp1 and DAI, and discuss some of their possible applications according to recent findings.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Proteínas Quinasas
/
Transducción de Señal
/
Proteínas Portadoras
/
Química
/
Fosfoproteínas Fosfatasas
/
Proteínas Mitocondriales
/
Factores de Necrosis Tumoral
/
Proteínas de Unión al ADN
/
Proteína Serina-Treonina Quinasas de Interacción con Receptores
/
GTP Fosfohidrolasas
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Protein & Cell
Año:
2012
Tipo del documento:
Artículo
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