Fine Mapping of a Deafness Mutation hml on Mouse Chromosome 10 / 西安交通大学学报·英文版
Academic Journal of Xi'
;
an Jiaotong University;(4): 209-212, 2004.
Artículo
en Inglés
| WPRIM
| ID: wpr-758029
ABSTRACT
OBJECTIVE:
to map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness.METHODS:
genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice.RESULTS:
1. hml was mapped on mouse Chr 10 (~43 cM from the centromere) suggests that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). 2. This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500kb area.
Texto completo:
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Índice:
WPRIM (Pacífico Occidental)
Idioma:
Inglés
Revista:
Academic Journal of Xi'an Jiaotong University
Año:
2004
Tipo del documento:
Artículo
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