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Retroperitoneal Sarcoma
Journal of the Korean Surgical Society ; : 28-35, 1998.
Artículo en Coreano | WPRIM | ID: wpr-75848
ABSTRACT
Soft-tissue sarcomas account for 1% of all solid tumors. Of these, less than 15% will occur in the retroperitoneum. Late diagnosis and large tumor size make retroperitoneal sarcomas difficult to resect. Resection with wide margins in all directions is rarely possible owing to proximity to vital structures. Radiation therapy is limited in dosage and, as with chemotherapy, has only been successful in a limited number of cases. These problems result in a poor prognosis. A series of patients with retroperitoneal sarcoma was reviewed with a focus on issues of surgical management and prognostic factors. A retrospective analysis of 12 patients with retroperitoneal sarcomas who had undergone operations at the Department of Surgery, Inje University Paik Hospital, Seoul, from 1980 through 1996 was performed. The mean age of the 10 adult patients was 51 years; the male-to-female ratio was 21. Eighty-three percent of the patients presented with an abdominal mass. The mean diameter of the tumors was 18.3 cm. Leimyosarcomas(33%) and liposarcomas(25%) comprised the majority of the histologic types. The tumor grades were I, II, and III in 3 cases each. Resection of the tumor was possible in 75%(9/12) of the cases, although 17% of the resections were incomplete. Resection of adjacent organs was required in 66% of the cases. The resectability rose from 60% in 80s to 86% in 90s, with no statistical significance, possibly due to the small number of cases in this series. There was no postoperative morbidity or mortality. Actuarial 1-, 3-, and 5-year survival rates after resection were 75%, 60%, and 30%, respectively. Four of the 7(57%) patients who underwent complete resections had recurrence 3 to 33 months after surgery; this was notable for grade II or III tumors only. Two patients with grade I tumors are alive 65 and 102 months respectively after complete resection and show no evidence of the disease. One patient who underwent an incomplete resection of the tumor died 50 months after the operation. Only the tumor grade was a significant prognostic factor(p=0.0207). In conclusion, a wide en-bloc resection of a retroperitoneal sarcoma with a clear margin in all directions is a prerequisite for long-term survival. Aggressive follow-up for the first 3 years after a complete resection of a high-grade tumor is justified.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Recurrencia / Sarcoma / Tasa de Supervivencia / Estudios Retrospectivos / Estudios de Seguimiento / Mortalidad / Quimioterapia / Diagnóstico Tardío / Seúl Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Adulto / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Journal of the Korean Surgical Society Año: 1998 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Pronóstico / Recurrencia / Sarcoma / Tasa de Supervivencia / Estudios Retrospectivos / Estudios de Seguimiento / Mortalidad / Quimioterapia / Diagnóstico Tardío / Seúl Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Adulto / Humanos País/Región como asunto: Asia Idioma: Coreano Revista: Journal of the Korean Surgical Society Año: 1998 Tipo del documento: Artículo