Microglial involvement in the development of olfactory dysfunction
Journal of Veterinary Science
;
: 319-330, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-758822
ABSTRACT
Olfactory impairment is the most common clinical manifestation among the elderly, and its prevalence increases sharply with age. Notably, growing evidence has shown that olfactory dysfunction is the first sign of neurodegeneration, indicating the importance of olfactory assessment as an early marker in the diagnosis of neurological disorders. In this review, we describe the nature of olfactory dysfunction and the advantage of using animal models in olfaction study, and we include a brief introduction to olfactory behavior tests widely used in this field. The contribution of microglia in the neurodegenerative processes including olfactory impairment is then discussed to provide a comprehensive description of the physiopathological role of interactions between neurons and microglia within the olfactory system.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Olfato
/
Prevalencia
/
Microglía
/
Enfermedades Neurodegenerativas
/
Modelos Animales
/
Diagnóstico
/
Escala de Evaluación de la Conducta
/
Enfermedades del Sistema Nervioso
/
Neuronas
Tipo de estudio:
Estudio diagnóstico
/
Estudio de prevalencia
Límite:
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Journal of Veterinary Science
Año:
2018
Tipo del documento:
Artículo
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