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Refractive Outcomes of 4-Year-old Children after Intravitreal Anti-vascular Endothelial Growth Factor versus Laser Photocoagulation for Retinopathy of Prematurity
Korean Journal of Ophthalmology ; : 272-278, 2019.
Artículo en Inglés | WPRIM | ID: wpr-760024
ABSTRACT

PURPOSE:

To compare long-term refractive outcomes associated with intravitreal anti-vascular endothelial growth factor (VEGF) versus laser photocoagulation treatment for retinopathy of prematurity (ROP).

METHODS:

A total of 52 eyes from 27 ROP patients treated at two tertiary referral-based hospitals from August 2006 to December 2013 were reviewed. The primary outcome was refractive error measured at the age of 4 years, accounting for within-patient inter-eye correlation. Secondary outcomes included the recurrence rate and treatment complications.

RESULTS:

The mean age at refraction was 4.7 ± 0.3 years in the laser group (n = 30) and 4.4 ± 0.3 years in the anti-VEGF group (n = 22). No significant differences were noted in gestational age, birthweight, post-menstrual age at treatment, or ROP stage/zone distribution between groups. Mean spherical equivalent was also not significantly different (−1.0 diopters in the laser group and −0.3 diopters in the injection group, p = 0.603). Clustered regression analysis revealed that only gestational age was significantly correlated with mean spherical equivalent (p < 0.001; 95% confidence interval, −0.007 to −0.002). Recurrence was noted in four eyes (13.3%) in the laser group, but this difference was not significant (p = 0.128). There were no major systemic complications reported in either group.

CONCLUSIONS:

Treatment type, whether laser or anti-VEGF injection, does not appear to influence long-term refractive outcomes in ROP. Concern regarding refractive outcomes should not be the most important factor when selecting ROP treatment modality.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Errores de Refracción / Retinopatía de la Prematuridad / Factores de Crecimiento Endotelial / Edad Gestacional / Factor A de Crecimiento Endotelial Vascular / Terapia por Láser / Inyecciones Intravítreas / Fotocoagulación Límite: Niño / Child, preschool / Humanos Idioma: Inglés Revista: Korean Journal of Ophthalmology Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Recurrencia / Errores de Refracción / Retinopatía de la Prematuridad / Factores de Crecimiento Endotelial / Edad Gestacional / Factor A de Crecimiento Endotelial Vascular / Terapia por Láser / Inyecciones Intravítreas / Fotocoagulación Límite: Niño / Child, preschool / Humanos Idioma: Inglés Revista: Korean Journal of Ophthalmology Año: 2019 Tipo del documento: Artículo