Acute Monoblastic Leukemia with t(11;17)(q23;q21): Fusion of the KMT2A(MLL) and MLLT6(AF17) Genes
Laboratory Medicine Online
;
: 258-262, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-760507
ABSTRACT
The KMT2A (formerly MLL) gene is associated with at least 10% of all cases of acute leukemia. More than 80 translocation partner genes of KMT2A have been discovered to date, six of which have been identified on the long arm of chromosome 17. Among these, the MLLT6 (formerly AF17) gene is located at 17q12 and fuses with the KMT2A gene in rare cases of acute leukemia. We report here a case of AML with a KMT2A/MLLT6 fusion that was confirmed using molecular genetic methods. According to a literature review, this is the first reported case of AML with a KMT2A/MLLT6 fusion in Korea.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Brazo
/
Cromosomas Humanos Par 17
/
Leucemia
/
Leucemia Monocítica Aguda
/
Corea (Geográfico)
/
Biología Molecular
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Laboratory Medicine Online
Año:
2019
Tipo del documento:
Artículo
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