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Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities
Natural Product Sciences ; : 130-135, 2019.
Artículo en Inglés | WPRIM | ID: wpr-760553
ABSTRACT
The purification of the MeOH extract from Impatiens balsamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 – 12). The structure of the new compound (1) was determined by spectral data analysis (1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1 – 12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with IC50 values of 26.89, 25.59, and 44.21 µM, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to 153.09 ± 4.66, 156.88 ± 8.86, and 157.34 ± 3.30%, respectively.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estadística como Asunto / Cromatografía / Fármacos Neuroprotectores / Concentración 50 Inhibidora / Factor de Crecimiento Nervioso / Balsaminaceae / Impatiens / Glioma Idioma: Inglés Revista: Natural Product Sciences Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Estadística como Asunto / Cromatografía / Fármacos Neuroprotectores / Concentración 50 Inhibidora / Factor de Crecimiento Nervioso / Balsaminaceae / Impatiens / Glioma Idioma: Inglés Revista: Natural Product Sciences Año: 2019 Tipo del documento: Artículo