Chemical Constituents of Impatiens balsamina Stems and Their Biological Activities
Natural Product Sciences
;
: 130-135, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-760553
ABSTRACT
The purification of the MeOH extract from Impatiens balsamina by repeated column chromatography led to the isolation of one new tetrahydronaphthalene (1), together with eleven known compounds (2 – 12). The structure of the new compound (1) was determined by spectral data analysis (1H and 13C-NMR, 1H-1H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS). Isolated compounds (1 – 12) were evaluated for their inhibitory effects on NO production in LPS-activated murine microglial BV-2 cells and their effects on NGF secretion from C6 glioma cells. Compounds 3, 7, and 10 reduced NO levels in LPS-activated murine microglial cells with IC50 values of 26.89, 25.59, and 44.21 µM, respectively. Compounds 1, 5, and 9 upregulated NGF secretion to 153.09 ± 4.66, 156.88 ± 8.86, and 157.34 ± 3.30%, respectively.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Estadística como Asunto
/
Cromatografía
/
Fármacos Neuroprotectores
/
Concentración 50 Inhibidora
/
Factor de Crecimiento Nervioso
/
Balsaminaceae
/
Impatiens
/
Glioma
Idioma:
Inglés
Revista:
Natural Product Sciences
Año:
2019
Tipo del documento:
Artículo
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