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Early reduced bone formation following burn injury in rats is not inversely related to marrow adiposity
Article en En | WPRIM | ID: wpr-760736
Biblioteca responsable: WPRO
ABSTRACT
OBJECTIVES: The objective of the study was to determine whether postburn reduction of bone formation occurred earlier than 2–3 weeks after burn injury and whether that reduction was inversely related to marrow adiposity. METHODS: Using a rat model of burn injury with sacrifice at 3 days postburn, we measured serum osteocalcin, a biomarker of bone formation, as well as a regulator of glucose metabolism, and counted tibial marrow adipocytes. RESULTS: Serum osteocalcin was reduced as early as 3 days postburn, coinciding with a trend toward decline in marrow adipocyte number rather than demonstrating an inverse relationship with adipocyte count. CONCLUSIONS: Factors that may be responsible for the dissociation include lack of circulating sclerostin, previously reported, increased energy demands following burn injury, increased sympathetic tone and perhaps oxidative stress. The relationship between bone formation and marrow adiposity is complex and subject to a variety of influences.
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Texto completo: 1 Índice: WPRIM Asunto principal: Osteogénesis / Médula Ósea / Quemaduras / Osteocalcina / Adipocitos / Estrés Oxidativo / Modelos Animales / Adiposidad / Glucosa / Metabolismo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Osteoporosis and Sarcopenia Año: 2019 Tipo del documento: Article
Texto completo: 1 Índice: WPRIM Asunto principal: Osteogénesis / Médula Ósea / Quemaduras / Osteocalcina / Adipocitos / Estrés Oxidativo / Modelos Animales / Adiposidad / Glucosa / Metabolismo Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Osteoporosis and Sarcopenia Año: 2019 Tipo del documento: Article