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Observational approach on regional lymph node in cutaneous melanomas of extremities
Radiation Oncology Journal ; : 51-59, 2019.
Artículo en Inglés | WPRIM | ID: wpr-760989
ABSTRACT

PURPOSE:

We evaluated failure pattern and treatment outcomes of observational approach on regional lymph node (LN) in cutaneous melanoma of extremities and sought to find clinico-pathologic factors related to LN metastases. MATERIAL AND

METHODS:

We retrospectively reviewed 73 patients with cutaneous melanoma of extremities between 2005 and 2016. If preoperative 18-F-fluorodeoxyglucose (FDG)-positron emission tomography/computed tomography (PET/CT) findings were non-specific for regional LNs, surgical resection of primary tumors with adequate margins was performed without sentinel lymph node biopsy (SLNB) and/or complete lymph node dissection (CLND), irrespective of tumor thickness or size. In patients with suspicious or positive findings on PET/CT or CT, SLNB followed by CLND or CLND was performed at the discretion of the surgeon. We defined LN dissection (LND) as SLNB and/or CLND.

RESULTS:

With a median follow-up of 38 months (range, 6 to 138 months), the dominant pattern of failure was regional failure (17 of total 23 events, 74%) in the observation group (n = 56). Pathologic LN metastases were significant factor for poor regional failure-free survival (hazard ration [HR] = 3.21; 95% confidence interval [CI], 1.03–10.33; p = 0.044) and overall survival (HR = 3.62; 95% CI, 1.02–12.94; p = 0.047) in multivariate analysis. In subgroup analysis for cN0 patients according to the preoperative PET/CT findings, LND group showed the better trend of LRFFS (log rank test, p = 0.192) and RFFS (p = 0.310), although which is not statistically significant.

CONCLUSION:

Observational approach on regional LNs on the basis of the PET/CT in patients with cutaneous melanoma of extremities showed the dominant regional failure pattern compared to upfront LND approach. To reveal regional lymph node status, SLND for cN0 patients may of importance in managing cutaneous melanoma patients.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Análisis Multivariante / Estudios Retrospectivos / Estudios de Seguimiento / Biopsia del Ganglio Linfático Centinela / Extremidades / Tomografía Computarizada por Tomografía de Emisión de Positrones / Escisión del Ganglio Linfático / Ganglios Linfáticos / Melanoma / Metástasis de la Neoplasia Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Radiation Oncology Journal Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Análisis Multivariante / Estudios Retrospectivos / Estudios de Seguimiento / Biopsia del Ganglio Linfático Centinela / Extremidades / Tomografía Computarizada por Tomografía de Emisión de Positrones / Escisión del Ganglio Linfático / Ganglios Linfáticos / Melanoma / Metástasis de la Neoplasia Tipo de estudio: Estudio observacional / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: Radiation Oncology Journal Año: 2019 Tipo del documento: Artículo