The use of tissue fiducial markers in improving the accuracy of post-prostatectomy radiotherapy
Radiation Oncology Journal
; : 43-50, 2019.
Article
en En
| WPRIM
| ID: wpr-760990
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE: The aim of this retrospective study was to investigate the use of a radiopaque tissue fiducial marker (TFM) in the treatment of prostate cancer patients who undergo post-prostatectomy radiotherapy (PPRT). TFM safety, its role and benefit in quantifying the set-up uncertainties in patients undergoing PPRT image-guided radiotherapy were assessed. MATERIALS AND METHODS: A total of 45 consecutive PPRT patients underwent transperineal implantation of TFM at the level of vesicourethral anastomosis in the retrovesical tissue prior to intensity-modulated radiotherapy. Prostate bed motion was calculated by measuring the position of the TFM relative to the pelvic bony anatomy on daily cone-beam computed tomography. The stability and visibility of the TFM were assessed in the initial 10 patients. RESULTS: No postoperative complications were recorded. A total of 3,500 images were analysed. The calculated prostate bed motion for bony landmark matching relative to TFM were 2.25 mm in the left-right, 5.89 mm in the superior-inferior, and 6.59 mm in the anterior-posterior directions. A significant 36% reduction in the mean volume of rectum receiving 70 Gy (rV₇₀) was achieved for a uniform planning target volume (PTV) margin of 7 mm compared with the Australian and New Zealand Faculty of Radiation Oncology Genito-Urinary Group recommended PTV margin of 10 mm. CONCLUSION: The use of TFM was safe and can potentially eliminate set-up errors associated with bony landmark matching, thereby allowing for tighter PTV margins and a consequent favourable reduction in dose delivered to the bladder and rectum, with potential improvements in toxicities.
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Texto completo:
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Índice:
WPRIM
Asunto principal:
Complicaciones Posoperatorias
/
Próstata
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Prostatectomía
/
Neoplasias de la Próstata
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Radioterapia
/
Recto
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Vejiga Urinaria
/
Estudios Retrospectivos
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Vestuario
/
Oncología por Radiación
Tipo de estudio:
Observational_studies
Límite:
Humans
País/Región como asunto:
Oceania
Idioma:
En
Revista:
Radiation Oncology Journal
Año:
2019
Tipo del documento:
Article