The antinociceptive effect of artemisinin on the inflammatory pain and role of GABAergic and opioidergic systems
The Korean Journal of Pain
;
: 160-167, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-761702
ABSTRACT
BACKGROUND:
Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and traditional therapeutic indications, which its interaction with the GABAergic system and antinoniceptive effects on neuropathic pain have shown. Therefore, this study was designed to evaluate the antinociceptive effects of artemisinin during inflammatory pain and interaction with the GABAergic and opioidergic systems by using a writhing response test.METHODS:
On the whole, 198 adult male albino mice were used in 4 experiments, including 9 groups (n = 6) each with three replicates, by intraperitoneal (i.p.) administration of artemisinin (2.5, 5, and 10 mg/kg), naloxone (2 mg/kg), bicuculline (2 mg/kg), saclofen (2 mg/kg), indomethacin (5 mg/kg), and ethanol (10 mL/kg). Writhing test responses were induced by i.p. injection of 10 mL/kg of 0.6% acetic acid, and the percentage of writhing inhibition was recorded.RESULTS:
Results showed significant dose dependent anti-nociceptive effects from artemisinin which, at a 10 mg/kg dose, was statistically similar to indomethacin. Neither saclofen nor naloxone had antinociceptive effects and did not antagonize antinociceptive effects of artemisinin, whereas bicuculline significantly inhibited the antinocicptive effect of artemisinin.CONCLUSIONS:
It seems that antinocicptive effects of artemisinin are mediated by GABAA receptors.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Bicuculina
/
Indometacina
/
Receptores de GABA
/
Ácido Acético
/
Etanol
/
Ácido gamma-Aminobutírico
/
Analgésicos
/
Analgésicos Opioides
/
Inflamación
/
Naloxona
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
The Korean Journal of Pain
Año:
2019
Tipo del documento:
Artículo
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