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Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead
The Korean Journal of Physiology and Pharmacology ; : 467-474, 2019.
Artículo en Inglés | WPRIM | ID: wpr-761817
ABSTRACT
Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead acetate (0.2%) in drinking water during pregnancy and lactation causes behavioral impairment and affects the expression of proteins associated with neurodevelopment. Lead exposure altered several parameters in rat offspring compared with those unexposed in open-field, social interaction, and pre-pulse inhibition tests. These parameters were restored to normal levels after clozapine treatment. Western blot and immunohistochemical analyses of the hippocampus revealed that several neurodevelopmental proteins were downregulated in lead-exposed rats. The expression was normalized after clozapine treatment (5 mg/kg/day, postnatal day 35–56). These findings demonstrate that downregulation of several proteins in lead-exposed rats affected subsequent behavioral changes. Our results suggest that lead exposure in early life may induce psychiatric disorders and treatment with antipsychotics such as clozapine may reduce their incidence.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Antipsicóticos / Agua Potable / Lactancia / Regulación hacia Abajo / Western Blotting / Incidencia / Factores de Riesgo / Clozapina / Modelos Animales / Trastornos del Neurodesarrollo Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio pronóstico / Factores de riesgo Límite: Animales / Embarazo Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Antipsicóticos / Agua Potable / Lactancia / Regulación hacia Abajo / Western Blotting / Incidencia / Factores de Riesgo / Clozapina / Modelos Animales / Trastornos del Neurodesarrollo Tipo de estudio: Estudio de etiología / Estudio de incidencia / Estudio pronóstico / Factores de riesgo Límite: Animales / Embarazo Idioma: Inglés Revista: The Korean Journal of Physiology and Pharmacology Año: 2019 Tipo del documento: Artículo