MicroRNAs in Asthma and Respiratory Infections: Identifying Common Pathways
Allergy, Asthma & Immunology Research
;
: 4-23, 2020.
Artículo
en Inglés
| WPRIM
| ID: wpr-762186
ABSTRACT
MicroRNAs (miRs) are single-stranded RNAs of 18-25 nucleotides. These molecules regulate gene expression at the post-transcriptional level; several of these are differentially expressed in asthma as well as in viral acute respiratory infections (ARIs), the main triggers of acute asthma exacerbations. In recent years, miRs have been studied in order to discover drug targets as well as biomarkers for diagnosis, disease severity and prognosis. We describe recent findings on miR expression and function in asthma and their role in the regulation of viral ARIs, according to cell tissue specificity and asthma severity. By combining the above information, we identify miRs that may be important in virus-induced asthma exacerbations. This is the first attempt to link miR profiles of asthmatic patients and ARI-induced miRs, addressing the question of whether there might be a specific miR deficit in asthmatic subjects that make them more susceptible and/or reactive to infection.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Especificidad de Órganos
/
Pronóstico
/
Infecciones del Sistema Respiratorio
/
Asma
/
ARN
/
Biomarcadores
/
Expresión Génica
/
Progresión de la Enfermedad
/
MicroARNs
/
Diagnóstico
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Allergy, Asthma & Immunology Research
Año:
2020
Tipo del documento:
Artículo
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