Your browser doesn't support javascript.
loading
Sensitivity of Various Evaluating Modalities for Predicting a Pathologic Complete Response After Preoperative Chemoradiation Therapy for Locally Advanced Rectal Cancer
Annals of Coloproctology ; : 275-281, 2019.
Artículo en Inglés | WPRIM | ID: wpr-762327
ABSTRACT

PURPOSE:

We investigated the sensitivity of various evaluating modalities in predicting a pathologic complete response (pCR) after preoperative chemoradiation therapy (PCRT) for locally advanced rectal cancer (LARC).

METHODS:

From a population of 2,247 LARC patients who underwent PCRT followed by surgery at Asan Medical Center, Seoul, Korea from January 2007 to June 2016, we retrospectively analyzed 313 patients (14.1%) who showed a pCR after surgery. Transrectal ultrasound (TRUS), high-resolution magnetic resonance imaging (MRI), abdominopelvic computed tomography (AP-CT), and endoscopy were performed within 2 weeks prior to surgery.

RESULTS:

Of the 313 patients analyzed, 256 (81.8%) had a pCR after radical surgery and 57 (18.2%) showed total regression after local excision. Preoperative TRUS, MRI, and AP-CT were performed in 283, 305, and 139 patients, respectively. Among these 3 groups, a prediction of a pCR of the primary tumor was made in 41 (14.5%), 51 (16.7%), and 27 patients (19.4%), respectively, before surgery. A prediction of a clinical N0 stage was made in 204 patients (88.3%) using TRUS, 130 (52.2%) using MRI, and 78 (65.5%) using AP-CT. Of the 211 patients who underwent endoscopy, 87 (41.2%) had a mention of clinical CR in their records. A prediction of a pathologic CR was made for 124 patients (39.6%) through at least one diagnostic modality.

CONCLUSION:

The various evaluation methods for predicting a pCR after PCRT show a predictive sensitivity of 0.15–0.41 for primary tumors and 0.52–0.88 for lymph nodes. Endoscopy is a relatively superior modality for predicting the pCR of the primary tumor of LARC patients.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias del Recto / Imagen por Resonancia Magnética / Reacción en Cadena de la Polimerasa / Estudios Retrospectivos / Ultrasonografía / Endoscopía / Seúl / Corea (Geográfico) / Ganglios Linfáticos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Annals of Coloproctology Año: 2019 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neoplasias del Recto / Imagen por Resonancia Magnética / Reacción en Cadena de la Polimerasa / Estudios Retrospectivos / Ultrasonografía / Endoscopía / Seúl / Corea (Geográfico) / Ganglios Linfáticos Tipo de estudio: Estudio diagnóstico / Estudio observacional / Estudio pronóstico Límite: Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Annals of Coloproctology Año: 2019 Tipo del documento: Artículo