Synergistic Effect of H1-Antihistamines on Topical Corticosteroids for Pruritus in Atopic Dermatitis: A Systematic Review and Meta-Analysis
Annals of Dermatology
; : 420-425, 2019.
Article
en En
| WPRIM
| ID: wpr-762356
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND: Although oral antihistamines (H1-histamine receptor antagonists) are the main treatment option for pruritus in general skin dermatosis, their effect in treating pruritus of atopic dermatitis (AD) has not yet been established. OBJECTIVE: We conducted a systematic review and meta-analysis to evaluate the effectiveness of combined therapy of H1-antihistamines and topical steroids. METHODS: We systematically searched MEDLINE, Embase, and CENTRAL databases for articles published from 1967 to 2015. We identified 1,206 studies and assessed their titles, abstract, and full-text. Random effects meta-analysis was used to calculate mean differences (MD) with 95% confidence intervals (CI). RESULTS: Two studies satisfying the inclusion criteria of antihistamine therapy with mandatory topical steroid use were selected. Comparing antihistamine monotherapy with combination therapy, patients treated with the addition of antihistamine to topical corticosteroids showed a statistically significant clinical improvement (standard MD, −0.24; 95% CI, −0.42 to −0.05; p=0.01). CONCLUSION: H1-antihistamines may have a synergistic effect when combined with topical steroids by influencing various associative factors of chronic pruritus in AD.
Palabras clave
Texto completo:
1
Índice:
WPRIM
Asunto principal:
Prurito
/
Piel
/
Enfermedades de la Piel
/
Esteroides
/
Corticoesteroides
/
Dermatitis
/
Dermatitis Atópica
/
Antagonistas de los Receptores Histamínicos
/
Antagonistas de los Receptores Histamínicos H1
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Humans
Idioma:
En
Revista:
Annals of Dermatology
Año:
2019
Tipo del documento:
Article