Is It Possible to Discontinue Tumor Necrosis Factor Antagonists after Psoriasis Remission?
Annals of Dermatology
;
: 495-501, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-762381
ABSTRACT
Tumor necrosis factor (TNF) antagonists are highly effective treatments for psoriasis. These agents provide the opportunity to improve disease activity and achieve clinical remission. Despite its efficacy, long-term use of biologics is associated with high financial costs and possibly life-threatening adverse events. Recently, there has been an increasing interest in discontinuing TNF antagonists in patients with psoriasis who have achieved a positive clinical response. However, there is a paucity of data and clinical guidelines concerning the cessation TNF antagonists in psoriasis treatment. Several factors, including cost, subsequent treatment efficacy, relative risks, and tolerability, should be considered before the decision is made to discontinue TNF antagonists. Well-designed clinical trials are necessary to identify factors that may trigger disease exacerbation after medication discontinuation in order to recognize the potential disadvantages of discontinuing treatment in patients who are previously successfully managed on TNF antagonists.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Psoriasis
/
Productos Biológicos
/
Factor de Necrosis Tumoral alfa
/
Resultado del Tratamiento
/
Progresión de la Enfermedad
Tipo de estudio:
Guía de Práctica Clínica
/
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Annals of Dermatology
Año:
2019
Tipo del documento:
Artículo
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