The Expression of Aldehyde Dehydrogenase Family in Breast Cancer / 한국유방암학회지
Journal of Breast Cancer
;
: 54-60, 2014.
Artículo
en Inglés
| WPRIM
| ID: wpr-7626
ABSTRACT
PURPOSE:
It is widely accepted that aldehyde dehydrogenase (ALDH) activity is a signature of breast cancer stem cells, and high activity has been reported to be associated with poor clinical outcome. The aim of this study was to assess the expression of members of the ALDH family of isozymes in breast cancer tissues and to evaluate the implications of the results.METHODS:
We analyzed paraffin-embedded tumor tissue from 160 patients with breast cancer. Immunohistochemistry (IHC) staining was performed on the slides using antibodies against different ALDH family members. We collated the IHC results with patient clinical characteristics and determined their prognostic value. In addition, we analyzed normal, hyperplastic, and carcinomatous tissues in situ to check their ALDH distributions.RESULTS:
All the tested ALDH members were detected in the various tissue types, but at different levels. Only ALDH 1A3 was found to be significantly associated with distant metastasis (p=0.001), disease-free survival (p<0.001), and overall survival (p<0.001).CONCLUSION:
The level of ALDH 1A3 in breast cancer tissue is a predictive marker of a poor clinical outcome.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Células Madre
/
Células Madre Neoplásicas
/
Mama
/
Neoplasias de la Mama
/
Inmunohistoquímica
/
Supervivencia sin Enfermedad
/
Aldehído Deshidrogenasa
/
Isoenzimas
/
Anticuerpos
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Breast Cancer
Año:
2014
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS