Genetic aspects of type 1 diabetes
Annals of Pediatric Endocrinology & Metabolism
;
: 143-148, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-762619
ABSTRACT
Type 1 diabetes mellitus (T1DM) is characterized by autoimmune destruction of pancreatic beta-cells in genetically predisposed individuals, eventually resulting in severe insulin deficiency. It is the most common form of diabetes in children and adolescents. Genetic susceptibility plays a crucial role in development of T1DM. The human leukocyte antigen complex plays a key role in the pathogenesis of T1DM. Furthermore, genome-wide association studies and linkage analysis have recently made a significant contribution to current knowledge relative to the impact of genetics on T1DM development and progression. This review focuses on current knowledge of genetics as a pathogenesis for T1DM. It also discusses mechanisms by which genes influence the risk of developing T1DM as well as the clinical and research applications of genetic risk scores in T1DM.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Predisposición Genética a la Enfermedad
/
Diabetes Mellitus Tipo 1
/
Estudio de Asociación del Genoma Completo
/
Genética
/
Insulina
/
Leucocitos
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
Annals of Pediatric Endocrinology & Metabolism
Año:
2019
Tipo del documento:
Artículo
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