Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis / Journal of the Korean Cancer Association, 대한암학회지
Cancer Research and Treatment
;
: 1653-1665, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-763196
ABSTRACT
PURPOSE:
This study was aimed to investigate the role of poly(A)-binding protein-interacting protein 1 (Paip1) in cervical carcinogenesis. MATERIALS ANDMETHODS:
The expression of Paip1 in normal cervical epithelial tissues and cervical cancer (CC) tissues were detected by immunohistochemistry. In vivo and in vitro assays were performed to validate effect of Paip1 on CC progression.RESULTS:
Paip1 was found to be up-regulated in CC, which was linked with shorter survival. Knockdown of Paip1 inhibited cell growth, induced apoptosis and cell cycle arrest in CC cells, whereas its overexpression reversed these effects. The in vivo tumor model confirmed the pro-tumor role of Paip1 in CC growth.CONCLUSION:
Altogether, the investigation demonstrated the clinical significance of Paip1 expression, which prompted that the up-regulated of Paip1 can presumably be a potential prognostic and progression marker for CC.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Pronóstico
/
Técnicas In Vitro
/
Inmunohistoquímica
/
Ciclo Celular
/
Neoplasias del Cuello Uterino
/
Apoptosis
/
Puntos de Control del Ciclo Celular
/
Carcinogénesis
Tipo de estudio:
Estudio pronóstico
Idioma:
Inglés
Revista:
Cancer Research and Treatment
Año:
2019
Tipo del documento:
Artículo
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