Targeting Microglial and Neuronal Toll-like Receptor 2 in Synucleinopathies
Experimental Neurobiology
;
: 547-553, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-763791
ABSTRACT
Synucleinopathies are neurodegenerative disorders characterized by the progressive accumulation of α-synuclein (α-syn) in neurons and glia and include Parkinson's disease (PD) and dementia with Lewy bodies (DLB). In this review, we consolidate our key findings and recent studies concerning the role of Toll-like receptor 2 (TLR2), a pattern recognition innate immune receptor, in the pathogenesis of synucleinopathies. First, we address the pathological interaction of α-syn with microglial TLR2 and its neurotoxic inflammatory effects. Then, we show that neuronal TLR2 activation not only induces abnormal α-syn accumulation by impairing autophagy, but also modulates α-syn transmission. Finally, we demonstrate that administration of a TLR2 functional inhibitor improves the neuropathology and behavioral deficits of a synucleinopathy mouse model. Altogether, we present TLR2 modulation as a promising immunotherapy for synucleinopathies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Enfermedad de Parkinson
/
Autofagia
/
Neuroglía
/
Cuerpos de Lewy
/
Enfermedades Neurodegenerativas
/
Demencia
/
Receptores Toll-Like
/
Receptor Toll-Like 2
/
Neuropatología
/
Inmunoterapia
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Experimental Neurobiology
Año:
2019
Tipo del documento:
Artículo
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