Identification of neoantigens derived from alternative splicing and RNA modification
Genomics & Informatics
;
: e23-2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-763824
ABSTRACT
The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a deeper understanding of the mechanism of neoantigen generation and better strategies to identify them will be required to realize the promise of neoantigen-based immunotherapy. Alternative splicing and RNA editing events are emerging mechanisms leading to neoantigen production. In this review, we outline recent work involving the large-scale screening of neoantigens produced by alternative splicing and RNA editing. We also describe strategies to predict and validate neoantigens from RNA sequencing data.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Péptidos
/
ARN
/
Tamizaje Masivo
/
Análisis de Secuencia de ARN
/
Edición de ARN
/
Empalme Alternativo
/
Carcinogénesis
/
Sistema Inmunológico
/
Inmunoterapia
Tipo de estudio:
Estudio diagnóstico
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Genomics & Informatics
Año:
2019
Tipo del documento:
Artículo
Similares
MEDLINE
...
LILACS
LIS