Comparison of the Clinical Characteristics and Outcomes between Leprosy-Affected Persons in Sorokdo and the General Population Affected by Chronic Hepatitis C in Korea
Gut and Liver
;
: 549-556, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-763871
ABSTRACT
BACKGROUND/AIMS:
Patients with Hansen’s disease are the most vulnerable to hepatitis C. However, no data on the treatment efficacy of direct-acting antiviral agents (DAAs) are available in this group. Therefore, we elucidated the prevalence and clinical outcomes of hepatitis C in persons affected by leprosy in Sorokdo, Jeollanam-do, Korea.METHODS:
We retrospectively included 50 leprosy patients with positive hepatitis C virus (HCV) RNA test results (group A) hospitalized at the Sorokdo National Hospital from May 2016 to March 2018 and 73 patients with chronic hepatitis C who were treated with DAAs at the Chonnam National University Hospital (group B) from May 2016 to December 2017.RESULTS:
Overall, at the Sorokdo National Hospital, positive HCV antibody and HCV RNA rates were 18.4% and 11.0%, respectively. The mean participant age was 76.5±7 years, and 58% of participants were men. The genotypes were type 1b in 44% (22 out of 50) and type 2 in 56% (28 out of 50). Sustained virologic response was achieved at a rate of 95.5% (21/22) in genotype 1b and 92.9% (26/28) in genotype 2 patients. Ribavirin-induced hemolytic anemia occurred in 57.1% (16/28) of patients with genotype 2. Among these, 28.5% (8/28) received blood transfusions.CONCLUSIONS:
Treatment efficacy was not different between the leprosy-affected population and the general population. However, severe ribavirin-induced hemolytic anemia requiring transfusion was present in 28.5% of genotype 2 patients. Therefore, we suggest ribavirin-free DAAs for the treatment of genotype 2 hepatitis C in leprosy-affected persons in the future.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Antivirales
/
Transfusión Sanguínea
/
ARN
/
Prevalencia
/
Estudios Retrospectivos
/
Resultado del Tratamiento
/
Hepatitis C
/
Hepacivirus
/
Hepatitis C Crónica
/
Genotipo
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2019
Tipo del documento:
Artículo
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