Familial Pancreatic Cancer and Surveillance of High-Risk Individuals
Gut and Liver
;
: 498-505, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-763877
ABSTRACT
Family history of pancreatic cancer (PC) is a risk factor for PC development, and the risk level correlates with the number of affected families. A case of PC with ≥1 PC cases in the first-degree relative is broadly defined as familial pancreatic cancer (FPC) and accounts for 5% to 10% of total PC cases. FPC possesses several epidemiological, genetic and clinicopathological aspects that are distinct from those of conventional PCs. In Western countries, FPC registries have been established since the 1990s, and high-risk individuals are screened to detect early PCs. For the pharmacotherapy of FPC, especially in cases with germline pathogenic BRCA mutations, regimens using platinum and poly (ADP-ribose) polymerase inhibitor have recently been studied for their effectiveness. To date, the concept of FPC has prevailed in Western countries, and it has begun to infiltrate into Eastern countries. As the genetic background and environmental conditions vary in association with ethnicity and living area, we need to establish our own FPC registries and accumulate data in Asian countries.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Pancreáticas
/
Platino (Metal)
/
Sistema de Registros
/
Factores de Riesgo
/
Pueblo Asiatico
/
Quimioterapia
/
Antecedentes Genéticos
Tipo de estudio:
Estudio de etiología
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Humanos
Idioma:
Inglés
Revista:
Gut and Liver
Año:
2019
Tipo del documento:
Artículo
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