Effect of Garcinia mangostana L. and propolis extracts on the inhibition of inflammation and alveolar bone loss in ligature-induced periodontitis in rats
International Journal of Oral Biology
;
: 55-61, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-764037
ABSTRACT
The purpose of this study was to evaluate the effect of mangosteen extract complex (MEC; Garcinia mangostana L. and propolis extracts) on the inhibition of inflammation and prevention of alveolar bone loss using a ligature-induced periodontitis model. Rat molars were ligatured with silk, and 1 µg/mL of lipopolysaccharide of Porphyromonas gingivalis was injected into the buccal and palatal gingivae of the teeth with or without treatment with the MEC. Changes in the expression levels of prostaglandin E₂ (PGE₂), interleukin-8 (IL-8), inducible nitric oxide synthase (iNOS), matrix metalloproteinase-8 (MMP-8), cyclooxygenase (COX)-1, and COX-2 in gingival tissues were evaluated using enzyme-linked immunosorbent assays. Alveolar bone loss around the ligated molars was examined using micro-computed tomography. The expression levels of PGE₂, IL-8, iNOS, MMP-8, COX-1, and COX-2 in gingival tissues were significantly reduced in the group treated with a mixture of 16 µg of mangosteen extract powder and 544 µg of propolis extract powder (ligation [Lig] + lipopolysaccharide extracted from P. gingivalis KCOM 2804 [L] + MEC 134). Additionally, alveolar bone loss was significantly reduced in the Lig + L + MEC 134 group compared with that in other groups. These results indicate that the MEC could be useful in preventing and treating periodontitis.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Periodontitis
/
Própolis
/
Diente
/
Ensayo de Inmunoadsorción Enzimática
/
Pérdida de Hueso Alveolar
/
Interleucina-8
/
Prostaglandina-Endoperóxido Sintasas
/
Porphyromonas gingivalis
/
Metaloproteinasa 8 de la Matriz
/
Garcinia
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
International Journal of Oral Biology
Año:
2019
Tipo del documento:
Artículo
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