Mesenchymal Stem Cells from the Wharton's Jelly of the Human Umbilical Cord: Biological Properties and Therapeutic Potential
International Journal of Stem Cells
;
: 218-226, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-764080
ABSTRACT
Wharton's jelly mesenchymal stem cells (WJ-MSCs) are a class of stem cells with high differentiative potential, an immuno-privileged status and easy access for collection, which raise no legal or ethical issues. WJ-MSCs exhibit several features of embryonic stem cells, both in the phenotypic and genetic aspects, with only a few differences, such as a shorter doubling time and a more extensive ex vivo expansion capacity. WJ-MSCs have immunomodulatory properties, involving both innate and adaptive immune responses. This review focuses on the role of WJ-MSCs in the management of graft-versus-host disease (GvHD), a life-threatening complication of the allogenic transplantation of hematopoietic stem cells. Different studies documented the beneficial effect of the infusion of WJ-MSCs, even when not fully HLA identical, in patients with severe GvHD, refractory to standard treatment. Finally, we summarized current ongoing clinical trials with WJ-MSCs and their potential in regenerative medicine.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Células Madre
/
Cordón Umbilical
/
Células Madre Hematopoyéticas
/
Medicina Regenerativa
/
Ética
/
Células Madre Embrionarias
/
Inmunomodulación
/
Gelatina de Wharton
/
Células Madre Mesenquimatosas
/
Enfermedad Injerto contra Huésped
Límite:
Humanos
Idioma:
Inglés
Revista:
International Journal of Stem Cells
Año:
2019
Tipo del documento:
Artículo
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