Anorexia Nervosa and Osteoporosis: Pathophysiology and Treatment
Journal of Bone Metabolism
;
: 133-143, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-764257
ABSTRACT
Anorexia nervosa (AN) affects 2.9 million people, many of whom experience bone loss and increased fracture risk. In this article, we review data on the underlying pathophysiology of AN-related osteoporosis and possible approaches to disease management. Available research suggests that low body weight and decreased gonadal function are the strongest predictors of bone loss and fractures in patients with AN. Additionally, other metabolic disturbances have been linked to bone loss, including growth hormone resistance, low leptin concentrations, and hypercortisolemia, but those correlations are less consistent and lack evidence of causality. In terms of treatment of AN-related bone disease, weight gain has the most robust impact on bone mineral density (BMD). Restoration of gonadal function seems to augment this effect and may independently improve BMD. Bisphosphonates, insulin-like growth factor 1 supplementation, and teriparatide may also be reasonable considerations, however need long-term efficacy and safety data.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteoporosis
/
Peso Corporal
/
Enfermedades Óseas
/
Hormona del Crecimiento
/
Aumento de Peso
/
Anorexia
/
Anorexia Nerviosa
/
Trastornos de Alimentación y de la Ingestión de Alimentos
/
Densidad Ósea
/
Teriparatido
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Bone Metabolism
Año:
2019
Tipo del documento:
Artículo
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