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The Roles of miRNAs in Medulloblastoma: A Systematic Review
Journal of Cancer Prevention ; : 79-90, 2019.
Artículo en Inglés | WPRIM | ID: wpr-764306
ABSTRACT
Medulloblastoma is considered one of the most threatening malignant brain tumors with an extremely high mortality rate in children. In the medulloblastoma, there are several genes and mutations found to work in an unregulated manner that works together to push the cells into a cancerous state. With the discovery of non-coding RNAs such as microRNAs (miRNAs), it has been shown that a different layer of gene regulations may be disrupted which would cause cancer. This fact led scientists to put their focus on the role of miRNAs in cancer. A mature miRNA contains a seed sequence which gives the miRNA to identify and attach to the interest mRNA; this attachment may lead degradation of mRNA or suppress of translation of the mRNA. The expression of miRNAs in medulloblastoma shows that some of these non-coding RNAs are overexpressed (OncomiRs) which help cells to proliferate and keep their stemness features. On the other hand, there are other forms of these miRNAs which normally inhibit cell proliferation and promote cell differentiation (tumor suppressor). These are down-regulated during cancer progression. In this systematic review, we attempted to gather several important studies on miRNAsrole in medulloblastoma tumors and the importance of these non-coding RNAs in the future study of cancer.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oncogenes / Control Social Formal / Neoplasias Encefálicas / ARN Mensajero / Diferenciación Celular / Mortalidad / Genes Supresores de Tumor / ARN no Traducido / MicroARNs / Proliferación Celular Tipo de estudio: Estudio pronóstico / Revisiones Sistemáticas Evaluadas Límite: Niño / Humanos Idioma: Inglés Revista: Journal of Cancer Prevention Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Oncogenes / Control Social Formal / Neoplasias Encefálicas / ARN Mensajero / Diferenciación Celular / Mortalidad / Genes Supresores de Tumor / ARN no Traducido / MicroARNs / Proliferación Celular Tipo de estudio: Estudio pronóstico / Revisiones Sistemáticas Evaluadas Límite: Niño / Humanos Idioma: Inglés Revista: Journal of Cancer Prevention Año: 2019 Tipo del documento: Artículo