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Association of Nutritional Status with Cognitive Stage in the Elderly Korean Population: The Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease
Journal of Clinical Neurology ; : 292-300, 2019.
Artículo en Inglés | WPRIM | ID: wpr-764346
ABSTRACT
BACKGROUND AND

PURPOSE:

Epidemiological studies have suggested the presence of strong correlations among diet, lifestyle, and dementia onset. However, these studies have unfortunately had major limitations due to their inability to fully control the various potential confounders affecting the nutritional status. The purpose of the current study was to determine the nutritional status of participants in the Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE) and to identify clinical risk factors for being at risk of malnutrition or being malnourished.

METHODS:

Baseline data from 212 participants [119 cognitively unimpaired (CU), 56 with mild cognitive impairment (MCI), and 37 with dementia] included in the KBASE database were analyzed. All participants underwent a comprehensive cognitive test and MRI at baseline. The presence of malnutrition at baseline was measured by the Mini Nutritional Assessment score. We examined the cross-sectional relationships of clinical findings with nutritional status using multiple logistic regression applied to variables for which p<0.2 in the univariate analysis. Differences in cortical thickness according to the nutritional status were also investigated.

RESULTS:

After adjustment for demographic, nutritional, and neuropsychological factors, participants with dementia had a significantly higher odds ratio (OR) for being at risk of malnutrition or being malnourished than CU participants [OR=5.98, 95% CI=1.20–32.97] whereas participants with MCI did not (OR=0.62, 95% CI=0.20–1.83). Cortical thinning in the at-risk/malnutrition group was observed in the left temporal area.

CONCLUSIONS:

Dementia was found to be an independent predictor for the risk of malnutrition compared with CU participants. Our findings further suggest that cortical thinning in left temporal regions is related to the nutritional status.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lóbulo Temporal / Encéfalo / Envejecimiento / Imagen por Resonancia Magnética / Estudios Epidemiológicos / Modelos Logísticos / Evaluación Nutricional / Oportunidad Relativa / Corteza Cerebral / Estado Nutricional Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Anciano / Humanos Idioma: Inglés Revista: Journal of Clinical Neurology Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Lóbulo Temporal / Encéfalo / Envejecimiento / Imagen por Resonancia Magnética / Estudios Epidemiológicos / Modelos Logísticos / Evaluación Nutricional / Oportunidad Relativa / Corteza Cerebral / Estado Nutricional Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo / Estudio de tamizaje Límite: Anciano / Humanos Idioma: Inglés Revista: Journal of Clinical Neurology Año: 2019 Tipo del documento: Artículo