The influence of BRCA variants of unknown significance on cancer risk management decision-making / 부인종양
Journal of Gynecologic Oncology
;
: e60-2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-764523
ABSTRACT
OBJECTIVE:
To compare gynecological cancer risk management between women with BRCA variants of unknown significance (VUS) to women with negative genetic testingMETHODS:
Ninety-nine patients whose BRCA genetic testing yielded VUS were matched with 99 control patients with definitive negative BRCA results at a single institution. Demographics and risk management decisions were obtained through chart review. Primary outcome was the rate of risk-reducing bilateral salpingo-oophorectomy (RRBSO). Chi square tests, t-tests, and logistic regression were performed, with significance of p<0.05.RESULTS:
VUS patients were more likely to be non-Caucasian (p=0.000) and of Ashkenazi-Jewish descent (p=0.000). There was no difference in gynecologic oncology referrals or recommendations to screen or undergo risk-reducing surgery for VUS vs. negative patients. Ultimately, 44 patients (22%) underwent RRBSO, with no significant difference in surgical rate based on the presence of VUS. Ashkenazi-Jewish descent was associated with a 4.5 times increased risk of RRBSO (OR=4.489; 95% CI=1.484–13.579) and family history of ovarian cancer was associated with a 2.6 times risk of RRBSO (OR=2.641; 95% CI=1.107–6.299).CONCLUSION:
In our institution, patients with VUS were surgically managed similarly to those with negative BRCA testing. The numbers of patients with VUS are likely to increase with the implementation of multi-gene panel testing. Our findings underscore the importance of genetic counseling and individualized screening and prevention strategies in the management of genetic testing results.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Neoplasias Ováricas
/
Derivación y Consulta
/
Gestión de Riesgos
/
Modelos Logísticos
/
Demografía
/
Pruebas Genéticas
/
Tamizaje Masivo
/
Medición de Riesgo
/
Síndrome de Cáncer de Mama y Ovario Hereditario
/
Asesoramiento Genético
Tipo de estudio:
Estudio de etiología
/
Estudio pronóstico
/
Factores de riesgo
/
Estudio de tamizaje
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Journal of Gynecologic Oncology
Año:
2019
Tipo del documento:
Artículo
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