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Effects of One-dose Varicella Vaccination on Disease Severity in Children during Outbreaks in Seoul, Korea
Journal of Korean Medical Science ; : e83-2019.
Artículo en Inglés | WPRIM | ID: wpr-764924
ABSTRACT

BACKGROUND:

In Korea, the incidence of varicella has increased despite the introduction of a universal one-dose vaccination for children aged 12–15 months in 2005. A previous study demonstrated that the vaccine effectiveness was insufficient to prevent against varicella. We assessed the effect of the varicella vaccination on disease severity.

METHODS:

Epidemiologic investigation of varicella cases in Seoul metropolitan area from 2015 to 2017 were used. Varicella-related symptoms such as rash were determined by the clinical practitioners. Disease severity of patients was assessed by the number of skin lesions and divided into mild (≤ 50) and moderate (51–249) to severe (≥ 250). Unconditional logistic regression analysis was performed and age was controlled.

RESULTS:

Among a total of 1,008 varicella cases reported, 869 cases were breakthrough cases and 139 were unvaccinated cases. The risk for occurrence of moderate-to-severe disease in the breakthrough group was 0.57 times less than that of the unvaccinated group.

CONCLUSION:

These data suggest that national varicella vaccination may have a significant effect on attenuation of disease severity in children.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piel / Modelos Logísticos / Varicela / Incidencia / Brotes de Enfermedades / Vacunación / Exantema / Seúl / Corea (Geográfico) Tipo de estudio: Estudio de incidencia / Estudio pronóstico / Factores de riesgo Límite: Niño / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2019 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Piel / Modelos Logísticos / Varicela / Incidencia / Brotes de Enfermedades / Vacunación / Exantema / Seúl / Corea (Geográfico) Tipo de estudio: Estudio de incidencia / Estudio pronóstico / Factores de riesgo Límite: Niño / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Korean Medical Science Año: 2019 Tipo del documento: Artículo