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Klotho and Postmenopausal Hormone Replacement Therapy in Women with Chronic Kidney Disease
Journal of Menopausal Medicine ; : 75-80, 2018.
Artículo en Inglés | WPRIM | ID: wpr-765743
ABSTRACT
Kidney function is highly susceptible to age-related changes, with chronic kidney disease (CKD) serving as an important cause of morbidity and mortality in older patients. The prevalence of CKD in Korea is higher among the elderly, relative to the general population, with the most significant increases seen following the onset of menopause. Under normal conditions, estrogen attenuates renal superoxide production and protects the kidney from oxidative damage. As estrogen levels are known to decrease by as much as 80% during menopause, this represents a significant risk for older women. Postmenopausal hormone replacement therapy (HRT) modulates the renin-angiotensin system, thereby reducing the progressive deterioration of renal function. Use of estrogen-based HRT has been shown to ameliorate renal function in postmenopausal women, and delay CKD progression. Renal expression of klotho, an important suppressor of aging, is markedly decreased in CKD patients, making it a promising candidate for use as a prognostic biomarker in CKD. Here, we review the key links between renal function, sex, age, and estrogen levels during menopause, and discuss the use of postmenopausal HRT in CKD attenuation.
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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sistema Renina-Angiotensina / Envejecimiento / Menopausia / Terapia de Reemplazo de Estrógeno / Prevalencia / Mortalidad / Posmenopausia / Superóxidos / Terapia de Reemplazo de Hormonas / Insuficiencia Renal Crónica Tipo de estudio: Estudio de prevalencia / Estudio pronóstico Límite: Anciano / Femenino / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Menopausal Medicine Año: 2018 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Sistema Renina-Angiotensina / Envejecimiento / Menopausia / Terapia de Reemplazo de Estrógeno / Prevalencia / Mortalidad / Posmenopausia / Superóxidos / Terapia de Reemplazo de Hormonas / Insuficiencia Renal Crónica Tipo de estudio: Estudio de prevalencia / Estudio pronóstico Límite: Anciano / Femenino / Humanos País/Región como asunto: Asia Idioma: Inglés Revista: Journal of Menopausal Medicine Año: 2018 Tipo del documento: Artículo