Application of Next Generation Sequencing Upon the Molecular Genetic Diagnosis of Deafness
Korean Journal of Audiology
;
: 1-5, 2012.
Artículo
en Inglés
| WPRIM
| ID: wpr-76689
ABSTRACT
The main objective of this review is to describe the new sequencing technologies called next generation sequencing (NGS) and its utility as a molecular genetic diagnosis tool in a medical field. Sanger method has dominated the genome sequencing industry for the past 30 years since its invention in 1975. It produced first human genome and still remains the gold standard for genome sequencing. However, it cannot meet the needs for enormous genetic data gathering and process because of its relatively long sequencing time and high cost per sample. NGS which parallelise the sequencing process, thereby increasing processing speed at a reduced cost per sample emerged to compensate for the weakness of the previous method. Currently NGS is used in some medical areas and its use is being widened. NGS also plays an important role in a study of genetically heterogenous hearing diseases. NGS is expected to mark a significant milestone in genomic research filed in a near future.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Genoma Humano
/
Genoma
/
Sordera
/
Invenciones
/
Audición
/
Biología Molecular
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Audiology
Año:
2012
Tipo del documento:
Artículo
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