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Comparison of Morphine and Remifentanil on the Duration of Weaning from Mechanical Ventilation / 대한구급학회지
The Korean Journal of Critical Care Medicine ; : 281-287, 2014.
Artículo en Inglés | WPRIM | ID: wpr-770838
ABSTRACT

BACKGROUND:

A randomized, multicenter, open-label, parallel group study was performed to compare the effects of remifentanil and morphine as analgesic drugs on the duration of weaning time from mechanical ventilation (MV).

METHODS:

A total of 96 patients with MV in 6 medical and surgical intensive care units were randomly assigned to either, remifentanil (0.1-0.2 mcg/kg/min, n = 49) or morphine (0.8-35 mg/hr, n = 47) from the weaning start. The weaning time was defined as the total ventilation time minus the sum of controlled mode duration.

RESULTS:

Compared with the morphine group, the remifentanil-based analgesic group showed a tendency of shorter weaning time (mean 143.9 hr, 89.7 hr, respectively p = 0.069). Secondary outcomes such as total ventilation time, successful weaning rate at the 7th of MV day was similar in both groups. There was also no difference in the mortality rate at the 7th and 28th hospital day. Kaplan-Meyer curve for weaning was not different between the two groups.

CONCLUSIONS:

Remifentanil usage during the weaning phase tended to decrease weaning time compared with morphine usage.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Respiración Artificial / Ventilación / Destete / Desconexión del Ventilador / Mortalidad / Cuidados Críticos / Analgésicos / Morfina Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: The Korean Journal of Critical Care Medicine Año: 2014 Tipo del documento: Artículo

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Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Respiración Artificial / Ventilación / Destete / Desconexión del Ventilador / Mortalidad / Cuidados Críticos / Analgésicos / Morfina Tipo de estudio: Ensayo Clínico Controlado / Estudio pronóstico Límite: Humanos Idioma: Inglés Revista: The Korean Journal of Critical Care Medicine Año: 2014 Tipo del documento: Artículo