Your browser doesn't support javascript.
loading
Outbreak of Imipenemase-1-Producing Carbapenem-Resistant Klebsiella pneumoniae in an Intensive Care Unit / 대한구급학회지
The Korean Journal of Critical Care Medicine ; : 29-38, 2017.
Artículo en Inglés | WPRIM | ID: wpr-770980
ABSTRACT

BACKGROUND:

Carbapenem-resistant Enterobacteriaceae (CRE) with acquired metallo β-lactamase (MBL) resistance have been increasingly reported worldwide and associated with significant mortality and morbidity. Here, an outbreak of genetically related strains of Klebsiella pneumoniae producing the imipenemase (IMP)-1 MBL in a medical intensive care unit (MICU) in Korea is reported.

METHODS:

Since isolating carbapenem-resistant K. pneumoniae (CRKP) at the MICU of the hospital on August 10, 2011, surveillance cultures for CRE in 31 hospitalized patients were performed from August to September 2011. Carbapenem resistance was determined based on the disk diffusion method outlined in the Clinical and Laboratory Standards Institute guidelines. Polymerase chain reaction (PCR) was performed for genes coding for β-lactamase. Associations among isolates were assessed via pulsed-field gel electrophoresis (PFGE). In addition, a surveillance study of environmental cultures and health-care workers (HCWs) was conducted in the MICU during the same time frame.

RESULTS:

During the study period, non-duplicated CRKP specimens were discovered in four patients in the MICU, suggestive of an outbreak. On August 10, 2011, CRKP was isolated from the sputum of a 79-year-old male patient who was admitted to the MICU. A surveillance study to detect additional CRE carriers by rectal swab revealed an additional three CRKP isolates. PCR and sequencing of the four isolates identified the presence of the IMP-1 gene. In addition, PFGE showed that the four isolated strains were genetically related. CRE was not identified in specimens taken from the hands of HCWs or other environmental sources during surveillance following the outbreak. Transmission of the carbapenemase-producing Enterobacteriaceae strain was controlled by isolation of the patients and strict contact precautions.

CONCLUSIONS:

This study shows that rapid and systemic detection of CRE and strict infection controls are important steps in preventing nosocomial transmission.
Asunto(s)

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Esputo / Reacción en Cadena de la Polimerasa / Brotes de Enfermedades / Mortalidad / Control de Infecciones / Electroforesis en Gel de Campo Pulsado / Cuidados Críticos / Farmacorresistencia Bacteriana / Difusión Tipo de estudio: Guía de Práctica Clínica / Estudio pronóstico Límite: Anciano / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: The Korean Journal of Critical Care Medicine Año: 2017 Tipo del documento: Artículo

Similares

MEDLINE

...
LILACS

LIS

Texto completo: Disponible Índice: WPRIM (Pacífico Occidental) Asunto principal: Neumonía / Esputo / Reacción en Cadena de la Polimerasa / Brotes de Enfermedades / Mortalidad / Control de Infecciones / Electroforesis en Gel de Campo Pulsado / Cuidados Críticos / Farmacorresistencia Bacteriana / Difusión Tipo de estudio: Guía de Práctica Clínica / Estudio pronóstico Límite: Anciano / Humanos / Masculino País/Región como asunto: Asia Idioma: Inglés Revista: The Korean Journal of Critical Care Medicine Año: 2017 Tipo del documento: Artículo