Activation of phagocytosis by immune checkpoint blockade / 医学前沿
Frontiers of Medicine
;
(4): 473-480, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-771294
ABSTRACT
Inhibition of macrophage-mediated phagocytosis has emerged as an essential mechanism for tumor immune evasion. One mechanism inhibiting the innate response is the presence of the macrophage inhibitory molecule, signal regulatory protein-α (SIRPα), on tumor-associated macrophages (TAMs) and its cognate ligand cluster of differentiation 47 (CD47) on tumor cells in the tumor microenvironment. On the basis of a recently discovered programmed death protein 1 (PD-1) in TAMs, we discuss the potential inhibitory receptors that possess new functions beyond T cell exhaustion in this review. As more and more immune receptors are found to be expressed on TAMs, the corresponding therapies may also stimulate macrophages for phagocytosis and thereby provide extra anti-tumor benefits in cancer therapy. Therefore, identification of biomarkers and combinatorial therapeutic strategies, have the potential to improve the efficacy and safety profiles of current immunotherapies.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fagocitosis
/
Terapéutica
/
Resultado del Tratamiento
/
Alergia e Inmunología
/
Proteínas Reguladoras de la Apoptosis
/
Microambiente Tumoral
/
Inmunoterapia
/
Macrófagos
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2018
Tipo del documento:
Artículo
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