Current advances for bone regeneration based on tissue engineering strategies / 医学前沿
Frontiers of Medicine
;
(4): 160-188, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-771298
ABSTRACT
Bone tissue engineering (BTE) is a rapidly developing strategy for repairing critical-sized bone defects to address the unmet need for bone augmentation and skeletal repair. Effective therapies for bone regeneration primarily require the coordinated combination of innovative scaffolds, seed cells, and biological factors. However, current techniques in bone tissue engineering have not yet reached valid translation into clinical applications because of several limitations, such as weaker osteogenic differentiation, inadequate vascularization of scaffolds, and inefficient growth factor delivery. Therefore, further standardized protocols and innovative measures are required to overcome these shortcomings and facilitate the clinical application of these techniques to enhance bone regeneration. Given the deficiency of comprehensive studies in the development in BTE, our review systematically introduces the new types of biomimetic and bifunctional scaffolds. We describe the cell sources, biology of seed cells, growth factors, vascular development, and the interactions of relevant molecules. Furthermore, we discuss the challenges and perspectives that may propel the direction of future clinical delivery in bone regeneration.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Osteogénesis
/
Regeneración Ósea
/
Diferenciación Celular
/
Biología Celular
/
Ingeniería de Tejidos
/
Péptidos y Proteínas de Señalización Intercelular
/
Trasplante de Células Madre Mesenquimatosas
/
Andamios del Tejido
/
Células Madre Mesenquimatosas
/
Metabolismo
Tipo de estudio:
Guía de Práctica Clínica
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2019
Tipo del documento:
Artículo
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