Everyone has a donor: contribution of the Chinese experience to global practice of haploidentical hematopoietic stem cell transplantation / 医学前沿
Frontiers of Medicine
;
(4): 45-56, 2019.
Artículo
en Inglés
| WPRIM
| ID: wpr-771319
ABSTRACT
Human leukocyte antigen (HLA)-matched donors for hematopoietic stem cell transplantation (HSCT) have long been scarce in China. Haploidentical (haplo) donors are available for the vast majority of patients, but toxicity has limited this approach. Three new approaches for haplo-HSCT originated from Italy, China, and USA in 1990 and have been developed to world-renowned system up to now. The Chinese approach have been greatly improved by implementing new individualized conditioning regimens, donor selection based on non-HLA systems, risk-directed strategies for graft-versus-host disease and relapse, and infection management. Haplo-HSCT has exhibited similar efficacy to HLA-matched HSCT and has gradually become the predominant donor source and the first alternative donor choice for allo-HSCT in China. Registry-based analyses and multicenter studies adhering to international standards facilitated the transformation of the unique Chinese experience into an inspiration for the refinement of global practice. This review will focus on how the new era in which "everyone has a donor" will become a reality in China.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Cirugía General
/
Prueba de Histocompatibilidad
/
Ensayos Clínicos Controlados Aleatorios como Asunto
/
China
/
Trasplante de Células Madre Hematopoyéticas
/
Neoplasias Hematológicas
/
Acondicionamiento Pretrasplante
/
Selección de Donante
/
Alergia e Inmunología
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Ensayo Clínico Controlado
/
Guía de Práctica Clínica
Límite:
Humanos
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Frontiers of Medicine
Año:
2019
Tipo del documento:
Artículo
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