Progress in epigenetic modification of mRNA and the function of m6A modification / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 775-783, 2019.
Artículo
en Chino
| WPRIM
| ID: wpr-771332
ABSTRACT
Messenger RNA (mRNA) can be modified by more than 100 chemical modifications. Among these modifications, N6-methyladenosine (m⁶A) is one of the most prevalent modifications. During the processes of cells differentiation, embryo development or stress, m⁶A can be modified on key mRNAs and regulate the progress of cells through modulating mRNA metabolism and translation. Other mRNA modifications, including N1-methyladenosine (m¹A), 5-methylcytosine (m⁵C) and pseudouridine, together with m⁶A form the epitranscriptome of mRNA that accurately modulate the mRNA translation. Here we review the types and characteristic of mRNA epigenetic modifications, especially the recent progresses of the function of m⁶A, we also expect the main research direction of m⁶A epigenetic modification in the future.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
ARN Mensajero
/
Diferenciación Celular
/
Adenosina
/
Procesamiento Postranscripcional del ARN
/
Regulación de la Expresión Génica
/
Epigénesis Genética
/
Desarrollo Embrionario
/
Genética
/
Metabolismo
Idioma:
Chino
Revista:
Chinese Journal of Biotechnology
Año:
2019
Tipo del documento:
Artículo
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