The roles of activated protein C in experimental trauma models / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 311-315, 2018.
Artículo
en Inglés
| WPRIM
| ID: wpr-771647
ABSTRACT
Trauma-induced coagulopathy is classified into primary and secondary coagulopathy, with the former elicited by trauma and traumatic shock itself and the latter being acquired coagulopathy induced by anemia, hypothermia, acidosis, and dilution. Primary coagulopathy consists of disseminated intravascular coagulation and acute coagulopathy of trauma shock (ACOTS). The pathophysiology of ACOTS is the suppression of thrombin generation and neutralization of plasminogen activator inhibitor-1 mediated by activated protein C that leads to hypocoagulation and hyperfibrinolysis in the circulation. This review tried to clarify the validity of activated protein C hypothesis that constitutes the main pathophysiology of the ACOTS in experimental trauma models.
Texto completo:
Disponible
Índice:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Heridas y Lesiones
/
Trastornos de la Coagulación Sanguínea
/
Proteína C
/
Trombina
/
Enfermedad Aguda
/
Inhibidor 1 de Activador Plasminogénico
/
Modelos Animales de Enfermedad
/
Coagulación Intravascular Diseminada
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Chinese Journal of Traumatology
Año:
2018
Tipo del documento:
Artículo
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